Promoterapy: increase promoter activity
of endogenous genes with CRISPRa

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One of the major limitations of current gene therapy approaches is the limited packaging capacity of viral vectors. Promoterapy overcome these limitations by using CRISPRa to target the promoter of endogenous genes and up-regulate their expression. The lab developed this technology in collaboration with Vania Broccoli's Lab in Italy. With this tool we are able to restore physiological gene expression in genetic diseases but also to increase the translation of ion channels that are able to decrease neuronal hyperexcitability in in vivo models of epilepsy.